Efektivitas Berbagai Modalitas Terapi Farmakologis dan Nonfarmakologis pada Skabies: Systematic Literatur Review
DOI:
https://doi.org/10.63265/jkti.v4i4.413Keywords:
benzyl benzoate, ivermectin, mass drug administration, permethrin, skabies, treatment failureAbstract
Skabies merupakan infestasi kulit menular akibat Sarcoptes scabiei var. hominis yang keberhasilan terapinya dipengaruhi oleh jenis obat, ketepatan aplikasi, kepatuhan, pengobatan kontak, dan risiko reinfestasi. Penelitian ini bertujuan mensintesis bukti mengenai efektivitas modalitas farmakologis dan nonfarmakologis dalam pengobatan dan pengendalian skabies pada manusia. Systematic review disusun mengikuti PRISMA 2020 dengan penelusuran PubMed, Scopus, dan Google Scholar untuk publikasi 2021–2026. Dari 919 rekaman yang diidentifikasi, 643 menjalani skrining, 40 laporan dinilai berdasarkan full text, dan 9 studi primer dimasukkan dalam sintesis akhir. Karena terdapat heterogenitas desain, populasi, regimen, dan outcome, dilakukan sintesis naratif tanpa meta-analysis. Hasil menunjukkan permethrin 5% menghasilkan clinical cure lebih tinggi dibandingkan ivermectin oral pada trial besar terbaru (88,5% vs. 71,8%). Studi lain menunjukkan efektivitas serupa antara ivermectin dan permethrin serta benzyl benzoate dan ivermectin (87% vs. 86%). Kombinasi ivermectin dan permethrin pada persistent scabies menghasilkan cure rate 83,8% dan recurrence 7,1%. Strategi berbasis komunitas juga menurunkan prevalensi secara substansial. Disimpulkan bahwa tidak terdapat satu modalitas yang universal paling unggul karena keberhasilan terapi dipengaruhi regimen, kepatuhan, pengobatan kontak, dan pencegahan reinfestasi
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Copyright (c) 2026 Sri Naita Purba, Gebby Adningtias Nurmina Loi, Neva Patricia Sinaga, Ester Paulina Br Tambunan, Asta Yabesman Hia, Gloria Martha Margareth Sinaga
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