Hubungan Kadar Interleukin 6 Terhadap Konversi Sputum Pada Pengobatan Tuberkulosis Paru
DOI:
https://doi.org/10.63265/jkti.v4i3.272Keywords:
Tuberkulosis paru, Interleukin-6 (IL-6), Konversi sputum BTAAbstract
Health Organization (WHO) melaporkan secara global pada tahun 2020, diperkirakan terdapat 10 juta kasus TB dengan Indonesia berada pada peringkat kedua penyumbang kasus TB terbanyak (8,5%) setelah India (26%). Pemeriksaan bakteriologis merupakan salah satu evaluasi pengobatan dalam menilai keberhasilan terapi TB, salah satunya dengan evaluasi pemeriksaan mikroskopis. Meskipun dengan berbagai kekurangan, penilaian dalam perubahan status sputum Basil Tahan Asam (BTA) setelah 2 bulan terapi masih digunakan sebagai marker respons terapi dan kesembuhan, hingga dinilai perlu dikembangkan pemeriksaan penunjang lain untuk memberikan informasi prognostik keberhasilan terapi. Penelitian ini bertujuan untuk mengetahui hubungan kadar IL-6 terhadap waktu konversi sputum BTA pada pengobatan TB paru. Penelitian dilaksanakan di RSUD Labuang Baji Makassar dengan jenis penelitian yang digunakan kuantitatif menggunakan desain observasional dan pendekatan kohort retroprospektif. Data analisis dengan menggunakan Uji regresi logistik digunakan untuk melihat hubungan antara kadar Interleukin-6 (Il-6) terhadap waktu konversi sputum pada pengobatan TB paru. Berdasarkan hasil penelitian terhadap 51 sampel yang memenuhi kriteria inklusi dan ekslusi, didapatkan hasil sebagai berikut : kadar Il-6 pada penelitian ini memiliki ambang batas 16,21 pg/ml dengan tingkat sensitivitas 92,31 % dan spesifisitas 89,47 % serta terdapat hubungan antara kadar Il-6 yang tinggi dengan tingkat kepositifan sputum BTA dan lama nya konversi sputum BTA pada pengobatan TB paru
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